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We show that hydrogen titanate (H2Ti3O7) nanotubes form strongly associated reversible nano-bio-conjugates with the vital respiratory protein, cytochrome c. Resonance Raman spectroscopy along with direct electrochemical studies indicate that in this nano-bio-conjugate, cytochrome c exists in an equilibrium of two conformational states with distinctly different formal redox potentials and coordination geometries of the heme center. The nanotube-conjugated cytochrome c also showed enhanced peroxidase activity similar to the membrane-bound protein that is believed to be an apoptosis initiator. This suggests that such a nanotube–cytochrome c conjugate may be a good candidate for cancer therapy applications.
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Journal | Data powered by TypesetNanotechnology |
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Publisher | Data powered by TypesetIOP Publishing |
Open Access | No |