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Comparison of a potentiometric and a micromechanical triglyceride biosensor
Published in
2009
PMID: 18804368
Volume: 24
   
Issue: 5
Pages: 1276 - 1280
Abstract
Sensitive biosensors for detection of triglyceride concentration are important. In this paper we report on two types of silicon based triglyceride sensors: an electrolyte-insulator-semiconductor capacitor (EISCAP) which is a potentiometric device and a polysilicon microcantilever. The detection principle for both sensors is based on the enzymatic hydrolysis of triglyceride though the sensing mechanisms are different: electronic for the EISCAP and mechanical for the microcantilever. The characteristics and performances of the two sensors are critically compared. The EISCAP sensor necessitates the presence of a buffer for stable measurements which limits the sensitivity of the sensor at low concentrations of the bioanalyte to 1 mM. The cantilever sensor works without a buffer which improves the lower level of sensitivity to 10 μm. Both sensors are found to give reproducible and reliable results. © 2008 Elsevier B.V. All rights reserved.
About the journal
JournalBiosensors and Bioelectronics
ISSN09565663
Open AccessNo
Concepts (43)
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    Cantilever sensors
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    DETECTION PRINCIPLES
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    EISCAP
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    Enzymatic hydrolysis
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    Low concentrations
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    Microcantilever
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    SEMICONDUCTOR CAPACITORS
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    SENSING MECHANISMS
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    SILICON BASED
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    STABLE MEASUREMENTS
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    TRIGLYCERIDE
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    TWO TYPES
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    Chemical sensors
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    Composite micromechanics
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    Hydrolysis
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    Polysilicon
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    Potentiometers (electric measuring instruments)
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    Semiconducting indium
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    Semiconducting silicon
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    Semiconducting silicon compounds
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    Sensors
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    Signal transduction
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    Biosensors
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    Silicon
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    Triacylglycerol
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    TRIACYLGLYCEROL LIPASE
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    Article
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    Biosensor
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    Comparative study
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    Controlled study
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    ELECTROLYTE INSULATOR SEMICONDUCTOR CAPACITOR
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    Reliability
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    Reproducibility
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    Sensitivity analysis
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    Biosensing techniques
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    Electrochemistry
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    Electrodes
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    Equipment design
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    Equipment failure analysis
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    Micro-electrical-mechanical systems
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    Reproducibility of results
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    Sensitivity and specificity
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    Triglycerides