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Cobalt(III)-Catalyzed Redox-Neutral Coupling of Acrylamides with Activated Alkenes via C–H Bond Activation
, Sudhakaran Keerthana Meledath, Manoharan Ramasamy
Published in Georg Thieme Verlag KG
2020
Volume: 52
   
Issue: 11
Pages: 1625 - 1633
Abstract

A cobalt(III)-catalyzed coupling of substituted acrylamides with maleimides in the presence of 30 mol% pivalic acid providing olefin-migrated succinimide derivatives in a redox-neutral manner is described. The coupling reaction was examined with various substituted acrylamides and maleimides. The scope of the C–H alkylation reaction was also examined with substituted acrylates. A possible reaction mechanism involving a five-membered cobaltocycle as a key intermediate is proposed.

About the journal
JournalScience of Synthesis
PublisherGeorg Thieme Verlag KG
Open AccessNo