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Biodegradation of chlorinated and non-chlorinated VOCs from pharmaceutical industries
, , P. Balasubramanian
Published in Springer
2011
PMID: 20799072
Volume: 163
   
Issue: 4
Pages: 497 - 518
Abstract
Biodegradation studies were conducted for major organic solvents such as methanol, ethanol, isopropanol, acetone, acetonitrile, toluene, chloroform, and carbon tetrachloride commonly used in pharmaceutical industries. Various microbial isolates were enriched and screened for their biodegradation potential. An aerobic mixed culture that had been previously enriched for biodegradation of mixed pesticides was found to be the most effective. All the organic solvents except chloroform and carbon tetrachloride were consumed as primary substrates by this mixed culture. Biodegradation rates of methanol, ethanol, isopropanol, acetone, acetonitrile, and toluene were measured individually in batch systems. Haldane model was found to best fit the kinetics of biodegradation. Biokinetic parameters estimated from single-substrate experiments were utilized to simulate the kinetics of biodegradation of mixture of substrates. Among the various models available for simulating the kinetics of biodegradation of multi-substrate systems, competitive inhibition model performed the best. Performance of the models was evaluated statistically using the dimensionless modified coefficient of efficiency (E). This model was used for simulating the kinetics of biodegradation in binary, ternary, and quaternary substrate systems. This study also reports batch experiments on co-metabolic biodegradation of chloroform, with acetone and toluene as primary substrates. The Haldane model, modified for inhibition due to chloroform, could satisfactorily predict the biodegradation of primary substrate, chloroform, and the microbial growth. © 2010 Springer Science+Business Media, LLC.
About the journal
JournalData powered by TypesetApplied Biochemistry and Biotechnology
PublisherData powered by TypesetSpringer
ISSN02732289
Open AccessNo
Concepts (55)
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    BATCH EXPERIMENTS
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    BATCH SYSTEMS
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    Best fit
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    BIO-KINETIC PARAMETERS
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    BIODEGRADATION POTENTIALS
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    BIODEGRADATION RATE
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    BIODEGRADATION STUDIES
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    CHLORINATED VOCS
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    Competitive inhibition
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    HALDANE MODEL
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    Iso-propanols
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    Microbial growth
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    MICROBIAL ISOLATES
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    MIXED CULTURES
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    MODIFIED COEFFICIENT
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    Pharmaceutical industry
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    SUBSTRATE INHIBITION KINETICS
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    SUBSTRATE SYSTEM
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    Acetone
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    Acetonitrile
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    Carbon tetrachloride
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    Degradation
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    Ethanol
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    Experiments
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    Industry
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    Methanol
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    Microbiology
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    Organic solvents
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    Substrates
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    Toluene
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    Volatile organic compounds
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    Biodegradation
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    2 PROPANOL
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    Alcohol
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    Chloroform
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    Organic solvent
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    Pesticide
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    Volatile organic compound
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    Article
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    Biodegradability
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    Chlorination
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    Concentration (parameters)
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    Drug industry
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    Isolation procedure
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    Mathematical model
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    Microorganism
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    Nonhuman
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    Screening
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    Bacteria
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    Binding, competitive
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    Biodegradation, environmental
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    Halogenation
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    Kinetics
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    Models, biological
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    Solvents