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Asymmetric Michael addition reaction using a chiral catalyst containingamino diol
Susan Abraham, Govindarajan Sundararajan
Published in
2002
Volume: 2002
   
Issue: 7
Pages: 212 - 226
Abstract
A C2-symmetric amino diol, (R,R)-2-(benzyl-(2-hydroxy-2- phenylethyl)-amino)-1-phenylethanol 1 was predominantly utilized to synthesise Li-Al heterobimetallic chiral catalyst. This catalyst is effective for carrying various Michael addition reactions. (R,R)-2-(p-vinyl benzyl-(2-hydroxy-2- phenylethyl)-amino)-1-phenylethanol 2 (Scheme 4), carrying a polymerisable vinyl tether, was also synthesised and used for preparing polymer anchored Li-Al heterobimetallic chiral catalyst. These catalysts are quite effective for enhancing various Michael addition reactions. The optimized reaction conditions produced Michael adducts in good yield with high enantiomeric excesses.
About the journal
JournalArkivoc
ISSN14246376
Open AccessNo
Concepts (28)
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    2 [4 VINYLBENZYL (2 HYDROXY 2 PHENYLETHYL)AMINO] 1 PHENYLETHANOL
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    2 BENZYL (2 HYDROXY 2 PHENYLETHYL)AMINO 1 PHENYLETHANOL
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    3 (4 METHYLPHENYLTHIO)CYCLOHEXANONE
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    3 (4 METHYLPHENYLTHIO)CYCLOPENTANONE
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    3 [BIS(BENZYLOXYCARBONYL)METHYL]CYCLOHEXANONE
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    3 [BIS(BENZYLOXYCARBONYL)METHYL]CYCLOPENTANONE
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    3 [BIS(ETHOXYCARBONYL)METHYL]CYCLOHEXANONE
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    3 [BIS(ETHOXYCARBONYL)METHYL]CYCLOPENTANONE
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    3 [BIS(TERT BUTOXYCARBONYL)METHYL]CYCLOHEXANONE
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    3 [BIS(TERT BUTOXYCARBONYL)METHYL]CYCLOPENTANONE
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    3 PHENYLTHIOCYCLOHEXANONE
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    3 PHENYLTHIOCYCLOPENTANONE
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    Alcohol
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    Aluminum
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    Ketone
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    Lithium
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    Malonic acid derivative
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    Metal complex
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    Polymer
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    Thiol derivative
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    Unclassified drug
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    Article
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    Catalyst
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    Chirality
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    Complex formation
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    Enantioselectivity
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    Michael addition
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    Synthesis