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Asymmetric capillary flow driven blood-plasma separation in microchannel with a hydrophobic patch and on-chip detection
, P. E. Rakesh, , Sneha Maria M
Published in Chemical and Biological Microsystems Society
2016
Pages: 699 - 700
Abstract
We report an asymmetric capillary-driven PDMS microchannel device with a hydrophobic patch for separation of plasma from sample blood and subsequent detection of glucose. A microchannel of cross-section 1000×400μm, with hydrophilic walls (on three sides) achieved by using oxygen plasma exposure enables capillary flow of blood introduced at the inlet. A hydrophobic patch (on all four sides) of width 1.0cm, located at 10mm from the device inlet, created in the microchannel impedes the flow of blood and the accumulated blood cells at the patch form a self-built-in filter to facilitate separation of plasma. 450nl of plasma was obtained within 15min.
About the journal
Journal20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Open AccessNo
Concepts (18)
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    Bioassay
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    Biochips
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    Blood
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    Capillarity
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    Capillary flow
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    Glucose
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    Hydrophobicity
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    Microarrays
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    Microchannels
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    ASYMMETRIC CAPILLARY
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    Blood cells
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    Blood plasma
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    BLOOD-PLASMA SEPARATION
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    HYDROPHOBIC PATCH
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    On chips
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    OXYGEN PLASMA EXPOSURE
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    Pdms microchannels
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    Blood vessels