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Arterial Stiffness in Elastic and Muscular Arteries: Measurement using ARTSENS Pen
P. M. Nabeel, , Malay Ilesh Shah,
Published in Institute of Electrical and Electronics Engineers Inc.
Various arterial segments in the macrovasculature exhibit heterogeneity in terms of the structural and functional properties. Owing to the difference in the structural composition, there exists a stiffness gradient from central to peripheral arteries. The loss in this gradient is multifactorial, such as aging, plaque formation, degradation of vessel elastin etcetera. This is a proven pathophysiological basis for cardiovascular risks, chronic kidney diseases, and end-organ damage. Clinical studies have reported the importance of measuring the local stiffness from peripheral arteries along with the central arteries. However, there is an unmet need for easy-to-use, portable, and non-expert operable tool for performing the stiffness measurements from individual target arteries. In this work, we have demonstrated the feasibility of using a highly compact image-free ultrasound device, ARTSENS® Pen, for measuring the central (carotid) and peripheral (brachial) arterial stiffness together. An in-vivo study was performed on a cohort of 19 subjects within the age group of 20 - 55 years for the same. The diameter and stiffness measurements performed in the recruited subjects were repeatable for both the arteries with a beat-to-beat coefficient of variation smaller than 5.3% and 7.5% respectively. The group average stiffness index for the brachial artery was observed to be higher than that of the carotid artery. The slope of the relationship between the carotid β stiffness versus the age of the subjects was higher compared to brachial, indicating higher stiffness progression rate for the carotid artery. A gradient reversal for the recruited population was observed for the older population. These observations were consistent with the theory and the earlier reported studies. In conclusion, the proposed technology provides a potential easy-to-use compact tool for performing fully automated stiffness measurements from multiple heterogeneous arterial sites. © 2019 IEEE.
About the journal
JournalData powered by TypesetMedical Measurements and Applications, MeMeA 2019 - Symposium Proceedings
PublisherData powered by TypesetInstitute of Electrical and Electronics Engineers Inc.
Open AccessNo
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