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Aqueous glucose measurement using differential absorption-based frequency domain optical coherence tomography at wavelengths of 1310 nm and 1625 nm
Pauline John, Murali Manoj, , , Suresh Ranga Rao
Published in OSA - The Optical Society
2014
Abstract
This work presents a combination of differential absorption technique and frequency domain optical coherence tomography for detection of glucose, which is an important analyte in medical diagnosis of diabetes. Differential absorption technique is used to detect glucose selectively in the presence of interfering species especially water and frequency domain optical coherence tomography (FDOCT) helps to obtain faster acquisition of depth information. Two broadband super-luminescent diode (SLED) sources with centre wavelengths 1586 nm (wavelength range of 1540 to 1640 nm) and 1312 nm (wavelength range of 1240 to 1380 nm) and a spectral width of ≈60 nm (FWHM) are used. Preliminary studies on absorption spectroscopy using various concentrations of aqueous glucose solution gave promising results to distinguish the absorption characteristics of glucose at two wavelengths 1310 nm (outside the absorption band of glucose) and 1625 nm (within the absorption band of glucose). In order to mimic the optical properties of biological skin tissue, 2% and 10% of 20% intralipid with various concentrations of glucose (0 to 4000 mg/dL) was prepared and used as sample. Using OCT technique, interference spectra were obtained using an optical spectrum analyzer with a resolution of 0.5 nm. Further processing of the interference spectra provided information on reflections from the surfaces of the cuvette containing the aqueous glucose sample. Due to the absorption of glucose in the wavelength range of 1540 nm to 1640 nm, a trend of reduction in the intensity of the back reflected light was observed with increase in the concentration of glucose. © 2015 SPIE-OSA.
About the journal
JournalData powered by TypesetOptics InfoBase Conference Papers
PublisherData powered by TypesetOSA - The Optical Society
ISSN1084-7529
Impact Factor1.230
Open AccessNo
Citation Styleunsrt
Sherpa RoMEO Archiving PolicyGreen
Concepts (19)
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    Absorption spectroscopy
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    COHERENT LIGHT
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    Diagnosis
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    Frequency domain analysis
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    Luminescence
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    Optical properties
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    Optical tomography
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    Spectrum analyzers
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    Tomography
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    Water absorption
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    ABSORPTION CHARACTERISTICS
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    AQUEOUS GLUCOSE SOLUTIONS
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    Differential absorption
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    DIFFERENTIAL ABSORPTION SPECTROSCOPY
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    DUAL WAVELENGTH
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    FREQUENCY DOMAIN OPTICAL COHERENCE TOMOGRAPHY
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    OPTICAL SPECTRUM ANALYZER
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    SUPERLUMINESCENT DIODE
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    Glucose