Header menu link for other important links
X
Antibacterial Activities of 4-Substituted-2-[(E)-{(1S,2R)/(1R,2S)-1-Hydroxy-1-Phenylpropan-2-Ylimino}Methyl]Phenol
Ponnurengan Malliappan Sivakumar,
Published in
2012
PMID: 22098701
Volume: 79
   
Issue: 2
Pages: 177 - 185
Abstract
A series of norephedrine-based Schiff bases (1a-6a and 1b-6b) were synthesized by reacting substituted salicylaldehydes with d-norephedrine or l-norephedrine. The structure of these compounds was confirmed by elemental analyses and spectroscopic techniques. The molecular structures of 5a and 6a have been determined by X-ray crystallography, which revealed that the compounds are in the oxoamino form, with bent intramolecular N-H···O (N···O≈2.58Å) hydrogen bonds and that they are associated in dimers bridged by linear intermolecular O-H···O (O···O≈2.69Å) hydrogen bonds. The density functional theory calculations on 5a confirmed that the oxoamino form is more stable than the phenolimino form by 12.2kcal/mol. All the compounds were evaluated for their antibacterial activity using resazurin dye as indicator by twofold dilution method against four bacteria namely, Bacillus subtilis (NCIM2718), Staphylococcus aureus (NCIM5021), Escherichia coli (NCIM2931), and Proteus vulgaris (NCIM2813). © 2011 John Wiley & Sons A/S.
About the journal
JournalChemical Biology and Drug Design
ISSN17470277
Open AccessNo
Concepts (29)
  •  related image
    Antiinfective agent
  •  related image
    NOREPHEDRINE
  •  related image
    Schiff base
  •  related image
    Antibacterial activity
  •  related image
    Article
  •  related image
    Bacillus subtilis
  •  related image
    Chemical structure
  •  related image
    Controlled study
  •  related image
    Dilution
  •  related image
    Escherichia coli
  •  related image
    Hydrogen bond
  •  related image
    Infrared spectroscopy
  •  related image
    Nonhuman
  •  related image
    Priority journal
  •  related image
    PROTEUS VULGARIS
  •  related image
    Staphylococcus aureus
  •  related image
    X ray crystallography
  •  related image
    Anti-bacterial agents
  •  related image
    Bacteria
  •  related image
    Crystallography, x-ray
  •  related image
    Hydrogen bonding
  •  related image
    Microbial sensitivity tests
  •  related image
    Molecular conformation
  •  related image
    Phenols
  •  related image
    PHENYLPROPANOLAMINE
  •  related image
    PROTEUS VULGARIS
  •  related image
    Schiff bases
  •  related image
    Stereoisomerism
  •  related image
    PROTEUS VULGARIS