The aim of the present investigation is to analyze the effect of the motion of horizontal (cases 1a–1d) and vertical walls (case 2a–2c) on the entropy generation and heat transfer in a porous square cavity during mixed convection. The cavity is subject to the thermal boundary conditions such as the hot bottom wall, cold side walls, and thermally insulated top wall. Analysis has been done for various fluids with Prandtl number, Prm = 0.026–7.2, Grashof number, Gr = 105, Reynolds number, Re = 10–100, and Darcy number, Dam = 10−4–10−2. Numerical results are presented using streamfunction (ψ), local entropy generation due to fluid friction (Sψ), isotherms (θ), and local entropy generation due to heat-transfer (Sθ) contours. In addition, the total entropy generation (Stotal), average Bejan number (Beav), and overall heat-transfer rate at the hot bottom wall (Formula presented.) are analyzed and discussed. © 2016, Copyright © Taylor & Francis Group, LLC.