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An integrated approach for mining precise RNA-based cervical cancer staging biomarkers
Published in Elsevier B.V.
2019
PMID: 31279709
Volume: 712
   
Abstract
Since international federation of gynecology and obstetrics (FIGO) staging is mainly based on clinical assessment, an integrated approach for mining RNA based biomarkers for understanding the molecular deregulation of signaling pathways and RNAs in cervical cancer was proposed in this study. Publicly available data were mined for identifying significant RNAs after patient staging. Significant miRNA families were identified from mRNA-miRNA and lncRNA-miRNA interaction network analyses followed by stage specific mRNA-miRNA-lncRNA association network generation. Integrated bioinformatic analyses of selected mRNAs and lncRNAs were performed. Results suggest that HBA1, HBA2, HBB, SLC2A1, CXCL10 (stage I), PKIA (stage III) and S100A7 (stage IV) were important. miRNA family enrichment of interacting miRNA partners of selected RNAs indicated the enrichment of let-7 family. Assembly of collagen fibrils and other multimeric structures_Homosapiens_R-HSA-2022090 in pathway analysis and progesterone_CTD_00006624 in DSigDB analysis were the most significant and SLC2A1, hsa-miR-188-3p, hsa-miR-378a-3p and hsa-miR-150-5p were selected as survival markers. © 2019 Elsevier B.V.
About the journal
JournalData powered by TypesetGene
PublisherData powered by TypesetElsevier B.V.
ISSN03781119
Open AccessNo
Concepts (57)
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    LONG UNTRANSLATED RNA
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    Messenger rna
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    Microrna
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    MICRORNA 150 5P
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    MICRORNA 188 3P
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    MICRORNA 378A 3P
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    RNA
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    Unclassified drug
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    Collagen
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    Tumor marker
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    Article
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    Bioinformatics
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    Cancer staging
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    Cancer survival
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    COLLAGEN FIBRIL
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    CXCL10 GENE
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    Data mining
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    Dna methylation
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    Gene
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    Gene expression
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    HBA1 GENE
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    HBA2 GENE
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    HBB GENE
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    PKIA GENE
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    Priority journal
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    RNA BINDING
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    S100A7 GENE
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    SLC2A1 GENE
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    Uterine cervix cancer
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    Biology
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    Chemistry
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    Complication
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    DISEASE EXACERBATION
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    Dna microarray
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    Female
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    Gene expression profiling
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    Gene expression regulation
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    Gene regulatory network
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    Genetics
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    Human
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    Metabolism
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    Papillomaviridae
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    PAPILLOMAVIRUS INFECTION
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    Procedures
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    Uterine cervix tumor
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    Virology
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    BIOMARKERS, TUMOR
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    Computational biology
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    DISEASE PROGRESSION
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    GENE EXPRESSION REGULATION, NEOPLASTIC
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    Gene regulatory networks
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    Humans
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    Micrornas
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    Oligonucleotide array sequence analysis
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    PAPILLOMAVIRUS INFECTIONS
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    RNA, NEOPLASM
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    Uterine cervical neoplasms