Different body postures that can be maintained for a certain duration with awareness are called yogaasanas. These asanas matter flexibility, coordination, and strength, while the breathing practices and meditation sharpens the mind for better awareness and reduce anxiety and thus adds quality into life. Other beneficial effects might involve a reduction of stress, blood pressure, and improvements in resilience, mood, and metabolic regulation. The asanas performed regularly for a short duration in hours is well studied in the literature. However, when performed for a long duration continuously for several hours (40-hour yogathon), without food and sleep has a significant effect in regulating homeostasis. The homeostasis is accessed through cardio-respiratory and galvanic skin response changes. The study shows the physiological changes after the yogathon and compares it with effects on physiology due to short term yoga. It also emphasizes on the reduction of dependency on food, because of energy compensation through yoga-asanas. © 2021 by IGI Global. All rights reserved.