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An expedient, one-pot, stepwise sequential approach for the regioselective synthesis of pyrazolines
S. Ganesan, M. Sarangapani,
Published in SAGE Publications Ltd
Volume: 45
Issue: 3-4
Pages: 326 - 333
An efficient approach for the synthesis of pyrazoline/pyrazole-tethered pyridinyl methanones is described via a one-pot, stepwise, sequential methodology using chalcones and pyridine-4-carbohydrazide as substrates through a Michael addition followed by cyclization. The reaction proceeds via a catalyst-, solvent-, work-up-, and column-chromatography-free method under melt conditions to provide the pyrazolines in short reaction times with high atom efficiency. © The Author(s) 2020.
About the journal
JournalData powered by TypesetJournal of Chemical Research
PublisherData powered by TypesetSAGE Publications Ltd