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An Electrophilic Trifluoromethylthiolation of Silylenol Ethers and β-Naphthols with Diethylaminosulfur Trifluoride and (Trifluoromethyl)trimethylsilane
Perumal Saravanan,
Published in Wiley-VCH Verlag
2018
Volume: 360
   
Issue: 15
Pages: 2894 - 2899
Abstract
An efficient and general trifluoromethylthiolation of silylenol ethers and β-naphthols have been accomplished employing the combination of diethylaminosulfur trifluoride (DAST) and (trifluoromethyl)trimethylsilane (CF3TMS) as source of electrophilic trifluoromethylthio moiety for the synthesis of α-trifluoromethylthiolated carbonyl compounds and β-naphthols in good yields. Important features of this method include wide functional group tolerance and use of readily available DAST/CF3TMS. Potential of the methodology was demonstrated via the synthesis of α-trifluoromethylthiolated (+)-4-cholesten-3-one and naphthoquinone. (Figure presented.). © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
About the journal
JournalData powered by TypesetAdvanced Synthesis and Catalysis
PublisherData powered by TypesetWiley-VCH Verlag
ISSN16154150
Open AccessNo