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Aerobic Oxidative C-H Olefination of Arylamides with Unactivated Olefins via a Rh(III)-Catalyzed C-H Activation
, Jambu S., Shambhavi C.N.
Published in ACS Publications
2021
Abstract
An efficient Rh(III)-catalyzed aerobic oxidative C-H alkenylation of arylamides with unactivated alkenes is described. The olefination reaction was compatible with various substituted arylamides including primary, secondary, and tertiary as well as functionalized unactivated olefins. Meanwhile, ortho mono/bis-alkylated arylamides were synthesized in the reaction of arylamides with norbornene. In the alkenylation reaction, molecular oxygen along with organic acid was used to regenerate the active catalyst for the next catalytic cycle. A possible reaction mechanism involving C-H activation/insertion/β-hydride elimination followed by aerobic oxidation was proposed and supported by the deuterium labeling studies. © 2021 American Chemical Society.
About the journal
JournalOrganic Letters
PublisherACS Publications
Open AccessNo