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A wireless magnetoelastic biosensor for the selective detection of low density lipoprotein (LDL) particles
X. Feng, , G.K. Mor, C.A. Grimes
Published in
Volume: 6
Issue: 3
Pages: 359 - 362
Lipoprotein particles are the main carriers of cholesterol in human blood circulation and play a key role in cholesterol transfer and metabolism. Recognition of the importance of cholesterol as a strong risk factor for coronary artery diseases has resulted in great interest in means to rapidly, and accurately, quantify lipoprotein fractions in the blood stream. This work presents a novel bio-sensing platform based on magnetoelastic resonance sensors for the detection of lipoprotein particles. The measurement is based on the selective bio-chemical reaction between a precipitator (dextran sulfate sodium salt and divalent metal Mg2+) and lipoproteins, producing insoluble precipitate which deposit onto the sensor surface, resulting in a change in the sensor resonance amplitude. The sensors show approximately a 20% change in resonance amplitude in a 10 mg/dl low density lipoprotein (LDL) solution, and an approximate 4% amplitude change in a high density lipoprotein (HDL) solution of the same concentration. Our results demonstrate that magnetoelastic sensors are suitable for selective detection of both LDL and HDL. Copyright © 2008 American Scientific Publishers. All rights reserved.
About the journal
JournalSensor Letters