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A rink-amide soluble support: High purity conotoxins and other peptides accessed with minimal reagents
Nimmashetti Naganna
Published in Royal Society of Chemistry
PMID: 31328741
Volume: 17
Issue: 30
Pages: 7238 - 7246
The use of peptides as therapeutics has been growing due to their biocompatibility. Solid phase peptide synthesis typically used to access these peptides requires excess reagents and/or microwave irradiation to drive reactions to completion because the reaction medium is heterogeneous. Reported herein is a soluble polynorbornene support containing rink amide attached sites for synthesizing oligopeptides and conotoxins in high purity using only 1.2 to 2 equivalents of coupling reagents. The support can be isolated as a precipitate from the reaction medium by adding ether. The loading capacity of the support can be easily determined by spectroscopy and can also be tuned by varying the monomer ratio. This support is promising for accessing peptides as the methodology uses minimal reagents and by-products can be easily separated. © 2019 The Royal Society of Chemistry.
About the journal
JournalData powered by TypesetOrganic and Biomolecular Chemistry
PublisherData powered by TypesetRoyal Society of Chemistry
Open AccessNo
Concepts (13)
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    Microwave irradiation
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    Synthesis (chemical)
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    Coupling reagents
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    Loading capacities
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    Monomer ratio
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    Reaction medium
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    Solid phase peptide synthesis
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    Soluble supports
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