In this work, a systematic review of the literature work done so far on the use of hydrate crystallization as a basis to develop data for the hydrate based gas separation (HBGS) process for the capture of CO₂ from fuel gas mixtures is presented. Such a gas mixture may arise in integrated gasification combined cycle (IGCC) power plants. A thorough assessment of the thermodynamic, kinetic factors and economic aspects of the HBGS process and critical comments are presented. Compared with competing technologies, high CO₂ capacity and the use of water as a solvent are key advantages for the HBGS process for CO₂ capture. Furthermore, in this review, a snapshot of the current state-of-the-art is presented and further research and development opportunities and pathways for commercializing the HBGS process for pre-combustion capture of CO₂ from IGCC power plants are discussed.