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A novel class of tyrosine derivatives as dual 5-LOX and COX-2/mPGES1 inhibitors with PGE 2 mediated anticancer properties
Shweta K. Sinha
,
Meera Ramanan
,
Puratchikody A
,
Gayathri Ramamoorthy
,
Umamaheswari E
,
Irfan N
,
Sinha S
,
Manju S L
,
Ramanan M
,
Ramamoorthy G
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Published in Royal Society of Chemistry
2019
DOI:
10.1039/c8nj04385j
Volume: 43
Issue: 2
Pages: 834 - 846
Abstract
Leukotriene and prostaglandin pathways are controlled by the enzymes, LOX and COX/mPGES1 respectively and are responsible for inflammatory responses.
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Figures & Tables (4)
Citations (1)
References (40)
Related Papers (3)
Journal Details
Authors (1)
Concepts (42)
Related Papers (3)
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About the journal
Journal
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New Journal of Chemistry
Publisher
Data powered by Typeset
Royal Society of Chemistry
ISSN
11440546
Open Access
No
Authors (1)
Mukesh Doble
Department Of Biotechnology
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Concepts (42)
3 [4 (BENZYLOXY) 3,5 DIIODOPHENYL] 2 METHANESULFONAMIDO PROPANOIC ACID
3 {3 CHLORO 4 [(PYRIMIDIN 4 YL)METHOXY]PHENYL} 2 METHANE SULFONAMIDOPROPANOIC ACID
3 {3,5 DIIODO 4 [(1 H 1,2,3 TRIAZOL 5 YL)METHOXY]PHENYL} 2 METHANE SULFONAMIDOPROPANOIC ACID
3 {3,5 DIIODO 4 [(1,2 OXAZOL 3 YL)METHOXY]PHENYL} 2 METHANE SULFONAMIDOPROPANOIC ACID
3 {3,5 DIIODO 4 [(PYRIDIN 4 YL)METHOXY]PHENYL} 2 METHANE SULFONAMIDOPROPANOIC ACID
3 {3,5 DIIODO 4 [(PYRIMIDIN 4 YL)METHOXY]PHENYL} 2 METHANE SUFLONAMIDOPROPANOIC ACID
Antineoplastic agent
ARACHIDONATE 5 LIPOXYGENASE
Ascorbic acid
BETA ACTIN
Chlorine
Cisplatin
CYCLOOXYGENASE 1
CYCLOOXYGENASE 2 INHIBITOR
Enzyme inhibitor
Lanthanum
Lead
LEUKOTRIENE
LICOFELONE
Messenger rna
PROSTAGLANDIN
PROSTAGLANDIN E SYNTHASE 1
PROSTAGLANDIN E2
TYROSINE DERIVATIVE
Unclassified drug
Antineoplastic activity
Antioxidant activity
Article
Controlled study
Drug synthesis
Enzyme activity
Enzyme inhibition
G2 phase cell cycle checkpoint
Hela cell line
Human
Human cell
In vitro study
MALIGNANT NEOPLASM
MRNA EXPRESSION LEVEL
Oxidation reduction reaction
Priority journal
S PHASE CELL CYCLE CHECKPOINT
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