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A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium
Debajyoti Basak, Sucheta Sridhar,
Published in Elsevier Ltd
2017
PMID: 28487073
Volume: 27
   
Issue: 13
Pages: 2886 - 2889
Abstract
Synthetic channels or pores that are easy to synthesize, stable and cation-selective are extremely attractive for the development of therapeutics and materials. Herein, we report a pore developed from a small tetrapeptide scaffold that shows a preference for sodium over lithium/potassium. The sodium selectivity is attributed to the appended oligoether tail at the C-terminus. A peptide dimer is proposed as the predominant cation-transporting pore. Such pyridine containing stable pores can be potentially utilized for the pH modulated ion transport. © 2017 Elsevier Ltd
About the journal
JournalData powered by TypesetBioorganic and Medicinal Chemistry Letters
PublisherData powered by TypesetElsevier Ltd
ISSN0960894X
Open AccessNo
Concepts (25)
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    AMPHOPHILE
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    Dimer
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    Lithium
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    Potassium
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    Pyridine
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    Sodium
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    Tetrapeptide
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    Lipid bilayer
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    Oligopeptide
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    Surfactant
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    Article
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    Carboxy terminal sequence
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    Controlled study
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    Ion transport
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    Membrane structure
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    Membrane transport
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    pH
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    Chemical structure
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    Chemistry
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    Synthesis
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    Hydrogen-ion concentration
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    Lipid bilayers
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    Molecular structure
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    Oligopeptides
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    Surface-active agents