Header menu link for other important links
A green process for the preparation of 11-{4-[2-(2-hydroxyethoxy) ethyl]-1-piperazinyl}dibenzo[b,f][1,4]thiazepine
A. V. Ramaswamy
Published in
Volume: 73
Issue: 4
Pages: 385 - 391
A green process for the synthesis of 11-{4-[2-(2-hydroxyethoxy)ethyl]-1- piperazinyl}dibenzo[b,f][1,4]thiazepine by the reaction of 11-(1-piperazinyl) dibenzo[b,f][1,4]thiazepine or its dihydrochloride salt with 2-(2-chloroethoxy) ethanol in the presence of an inorganic base and water is reported (conversion 99.9 % in a short time and without any impurities). The metal halides and phase transfer catalyst increase the rate of reaction, especially in water as the solvent.
About the journal
JournalJournal of the Serbian Chemical Society
Open AccessYes