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A computational model that links non-periodic vasomotion to enhanced oxygenation in skeletal muscle
Published in
2007
PMID: 17524429
Volume: 209
   
Issue: 2
Pages: 486 - 499
Abstract
We propose a model of a capillary network in which chaotic capillary activity is crucial for efficient oxygenation of a muscle fiber. Tissue oxygenation by microcirculation is controlled by a complex pattern of opening and closing of precapillary sphincters, a phenomenon known as vasomotion. We model the individual precapillary sphincter as a non-linear oscillator that exhibits perfectly periodic vasomotion in isolation. The precapillary sphincters surrounding an active fiber are considered as a network; specific modes of interaction within this network result in complex patterns of vasomotion. In our model, efficient oxygenation of the fiber depends crucially on the mode of interaction among the vasomotions of the individual capillaries. Network interactions that lead to chaotic vasomotion are found to be essential for meeting the tissue oxygen demands precisely. Interactions that cause regular rhythmic patterns of vasomotion fail to meet oxygenation demands accurately. © 2007 Elsevier Inc. All rights reserved.
About the journal
JournalMathematical Biosciences
ISSN00255564
Open AccessNo
Concepts (31)
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    Chaotic systems
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    Computational methods
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    Mathematical models
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    Oxygenation
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    MUSCLE FIBER
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    VASCULAR CONTROL
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    VASOMOTION
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    Muscle
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    Cardiovascular system
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    Modeling
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    Numerical model
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    Physiology
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    Accuracy
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    Article
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    Capillary
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    Chaotic dynamics
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    Mathematical computing
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    Microcirculation
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    Nonlinear system
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    Oscillator
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    OXYGEN TISSUE LEVEL
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    Skeletal muscle
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    Statistical model
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    VASOMOTOR REFLEX
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    Animals
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    CAPILLARIES
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    Mathematics
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    Models, biological
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    MUSCLE, SKELETAL
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    Nonlinear dynamics
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    Oxygen